反応 #1605805

反応方程式

4-(3-Amino-4-phenylphenyl)butyric acid

tosylic acid hydrate

water

→

benzyl 4-(3-amino-4-phenylphenyl)butyrate tosylate

収率 171.2%

溶媒

toluene

benzyl alcohol

反応条件

後処理

1. 1
   workup.ADDITIONwere added
2. 2
   温度the mixture was heated
3. 3
   その他removed by a Dean-Stark trap
4. 4
   濃縮The reaction solution was concentrated under reduced pressure
5. 5
   その他a solid obtained
6. 6
   洗浄was washed with a mixed solvent of hexane-ethyl acetate (4:1)
7. 7
   ろ過The solid was collected by filtration
8. 8
   その他dried under reduced pressure

実験手順

To a suspension of 4-(3-Amino-4-phenylphenyl)butyric acid (21.6 g, 84.6 mmol) in toluene (300 mL), benzyl alcohol (50 mL) and tosylic acid hydrate (17.7 g, 93.0 mmol) were added, and the mixture was heated under reflux for 5 hours with water removed by a Dean-Stark trap. The reaction solution was concentrated under reduced pressure and a solid obtained was washed with a mixed solvent of hexane-ethyl acetate (4:1). The solid was collected by filtration and dried under reduced pressure to obtain benzyl 4-(3-amino-4-phenylphenyl)butyrate tosylate (41.2 g).

出典