反応 #1605803

反応方程式

3-(4-bromobenzoyl)propionic acid

nitric acid

→

3-(4-bromo-3-nitrobenzoyl)propionic acid

反応条件

後処理

1. 1
   workup.ADDITIONthe reaction solution was poured onto ice
2. 2
   その他The solid which precipitated
3. 3
   ろ過was collected by filtration
4. 4
   洗浄washed with purified water
5. 5
   その他dried under reduced pressure

実験手順

Under salt-ice cooling, 3-(4-bromobenzoyl)propionic acid (75.0 g, 291.7 mmol) was added to fuming nitric acid (200 mL) in portions at such a rate that the temperature of the reaction solution could be maintained at −5° C. or lower. After stirring at −12° C. to −10° C. for 1 hour, the reaction solution was poured onto ice. The solid which precipitated was collected by filtration, washed with purified water, and thereafter dried under reduced pressure to obtain 3-(4-bromo-3-nitrobenzoyl)propionic acid (91.0 g).

出典