反応 #1605801

反応方程式

tert-Butyl trans-3-(3-nitro-4-phenylphenyl)acrylate

→

tert-butyl 3-(3-amino-4-phenylphenyl)propionate

収率 99.9%

溶媒

methanol

ethyl acetate

反応条件

後処理

1. 1
   ろ過The reaction solution was filtered through celite
2. 2
   濃縮the filtrate was concentrated under reduced pressure

実験手順

tert-Butyl trans-3-(3-nitro-4-phenylphenyl)acrylate (6.52 g, 20.0 mmol) was dissolved in methanol (100 mL) and ethyl acetate (100 mL), 10% palladium-carbon (500 mg) was added thereto, and the mixture was stirred under a hydrogen atmosphere at room temperature for 16 hours. The reaction solution was filtered through celite and the filtrate was concentrated under reduced pressure to obtain tert-butyl 3-(3-amino-4-phenylphenyl)propionate (5.94 g).

出典