反応 #1605799

反応方程式

5-((R)-2-Azido-1-hyroxyethyl)-8-benzyloxy-1H-quinolin-2-one

acetic acid

→

5-((R)-2-amino-1-hyroxyethyl)-8-hydroxy-1H-quinolin-2-one acetate

反応条件

後処理

1. 1
   その他The catalyst was removed by filtration
2. 2
   濃縮the filtrate was concentrated under reduced pressure
3. 3
   workup.ADDITIONTo the residue were added methanol (100 mL) and ethyl acetate (100 mL)
4. 4
   workup.STIRRINGthe mixture was stirred
5. 5
   ろ過The precipitate was collected by filtration
6. 6
   その他dried

実験手順

5-((R)-2-Azido-1-hyroxyethyl)-8-benzyloxy-1H-quinolin-2-one (16.8 g, 49.9 mol) was suspended in acetic acid (50 mL), a catalytic amount of palladium hydroxide-carbon was added thereto, and the solution was stirred under a hydrogen atmosphere overnight. The catalyst was removed by filtration and the filtrate was concentrated under reduced pressure. To the residue were added methanol (100 mL) and ethyl acetate (100 mL), and the mixture was stirred. The precipitate was collected by filtration and dried to obtain 5-((R)-2-amino-1-hyroxyethyl)-8-hydroxy-1H-quinolin-2-one acetate (12.5 g).

出典