反応 #1605795

反応方程式

5-Acetyl-8-hydroxy-1H-quinolin-2-one

potassium carbonate

benzyl bromide

→

5-acetyl-8-benzyloxy-1H-quinolin-2-one

収率 87.4%

溶媒

N,N-dimethylformamide

反応条件

後処理

1. 1
   その他The insoluble matter was removed by filtration
2. 2
   洗浄washed with N,N-dimethylformamide
3. 3
   workup.ADDITIONThe filtrate and the washing were mixed
4. 4
   濃縮concentrated under reduced pressure
5. 5
   workup.ADDITIONTo the residue was added
6. 6
   その他purified water (3.3 L)
7. 7
   workup.STIRRINGthe mixture was stirred at room temperature overnight
8. 8
   ろ過The precipitate was collected by filtration
9. 9
   洗浄washed with purified water
10. 10
    その他dried under vacuum

実験手順

5-Acetyl-8-hydroxy-1H-quinolin-2-one (430 g, 2.12 mol) was suspended in N,N-dimethylformamide (3.3 L), potassium carbonate (298 g, 2.16 mol) and subsequently benzyl bromide (298 g, 2.11 mol) were added thereto, and the mixture was stirred at room temperature for 2 hours. The insoluble matter was removed by filtration and washed with N,N-dimethylformamide. The filtrate and the washing were mixed and concentrated under reduced pressure. To the residue was added purified water (3.3 L) and the mixture was stirred at room temperature overnight. The precipitate was collected by filtration, washed with purified water, and dried under vacuum to obtain 5-acetyl-8-benzyloxy-1H-quinolin-2-one (541 g).

出典