反応 #1605794

反応方程式

8-Quinolinol

meta-chloroperbenzoic acid

→

8-hydroxyquinoline-N-oxide

収率 81.6%

溶媒

dichloromethane

反応条件

後処理

1. 1
   その他Insoluble matter was removed by filtration
2. 2
   洗浄was washed with dichloromethane
3. 3
   workup.ADDITIONThe filtrate and the washing were mixed
4. 4
   濃縮concentrated under reduced pressure
5. 5
   workup.ADDITIONTo the residue, 2% aqueous ammonia (2.1 L) was added
6. 6
   workup.STIRRINGthe mixture was stirred at room temperature overnight
7. 7
   ろ過The precipitate was collected by filtration
8. 8
   洗浄washed with purified water
9. 9
   その他dried under reduced pressure

実験手順

8-Quinolinol (351 g, 2.42 mol) was dissolved in dichloromethane (3.5 L) and, under ice-water cooling, meta-chloroperbenzoic acid (675.3 g, 2.74 mol) was added thereto in portions, and the mixture was stirred at room temperature for 2 hours. Insoluble matter was removed by filtration and was washed with dichloromethane. The filtrate and the washing were mixed and concentrated under reduced pressure. To the residue, 2% aqueous ammonia (2.1 L) was added and the mixture was stirred at room temperature overnight. The precipitate was collected by filtration, washed with purified water, and dried under reduced pressure to obtain 8-hydroxyquinoline-N-oxide (318.4 g).

出典