反応 #1603330

反応方程式

2-(benzyloxy)-6-bromopyridine

pyrrolidine

water

→

2-(benzyloxy)-6-(pyrrolidin-1-yl)pyridine

収率 95.3%

溶媒

ethyl acetate hexane

反応条件

後処理

1. 1
   その他the mixture was reacted
2. 2
   その他at 150° C.
3. 3
   その他for 10 min
4. 4
   抽出extracted twice with 100 ml portions of ethyl acetate
5. 5
   その他the organic layer was separated
6. 6
   その他dried over anhydrous and
7. 7
   その他to remove the solvent
8. 8
   その他The residue thus obtained

実験手順

In a dried microwave reactor, 526 mg (2.0 mmol) of 2-(benzyloxy)-6-bromopyridine and 1.70 ml (20 mmol) of pyrrolidine were placed, and the mixture was reacted using microwave at 150° C. for 10 min. The reaction mixture was mixed with 20 ml of water, extracted twice with 100 ml portions of ethyl acetate, and the organic layer was separated dried over anhydrous and kept under a reduced pressure to remove the solvent. The residue thus obtained was subjected to column chromatography using 10% ethyl acetate/hexane as an eluent to obtain 485 mg (yield 95%) of 2-(benzyloxy)-6-(pyrrolidin-1-yl)pyridine.

出典