反応 #1602

反応方程式

3-cyano-5-(4-chlorophenyl)-2-pyridinone

→

5-(4-chlorophenyl)-2-pyridinone

収率 75.6%

溶媒

H3PO4

反応条件

後処理

1. 1
   温度was heated
2. 2
   温度at reflux for 16 hours
3. 3
   ろ過filtered

実験手順

A mixture of 3-cyano-5-(4-chlorophenyl)-2-pyridinone (4.6 g) and 85% H3PO4 (60 ml) was heated at reflux for 16 hours. The resulting mixture was cooled to room temperature, poured into ice/water and filtered yielding 3.1 g of 5-(4-chlorophenyl)-2-pyridinone as a yellow solid.

出典