反応 #160102

反応方程式

Tert-butyl 8-(2,2-difluoropropyl)-10-(methoxymethyl)-11-oxa-3,8-diazaspiro[5.5]undecane-3-carboxylate

HCl

dioxane

→

4-(2,2-difluoropropyl)-2-(methoxymethyl)-1-oxa-4,9-diazaspiro[5.5]undecane hydrochloride

収率 99.0%

反応条件

後処理

1. 1
   その他The solvent was evaporated

実験手順

Tert-butyl 8-(2,2-difluoropropyl)-10-(methoxymethyl)-11-oxa-3,8-diazaspiro[5.5]undecane-3-carboxylate (77.0 mg, 0.204 mmol) was treated with HCl in dioxane (509 μL of 4 M, 2.04 mmol) and stirred for 2 h. The solvent was evaporated to provide 4-(2,2-difluoropropyl)-2-(methoxymethyl)-1-oxa-4,9-diazaspiro[5.5]undecane hydrochloride as yellow solid (64 mg, 0.20 mmol, 99%). ESI-MS m/z calc. 278.2. Found 279.3 (M+1)+; Retention time: 0.79 minutes (3 min run).

出典