反応 #1601

反応方程式

acetic

2-(4-chlorophenyl)-3-dimethylaminopropenal

sodium methoxide

cyanoacetamide

→

3-cyano-5-(4-chlorophenyl)-2-pyridinone

溶媒

water

methanol

反応条件

後処理

1. 1
   温度the resulting suspension was refluxed overnight
2. 2
   その他During this time a yellow solid was formed
3. 3
   workup.ADDITIONwas added
4. 4
   ろ過The resulting yellow orange solid was filtered off
5. 5
   洗浄washed several times with water
6. 6
   その他dried

実験手順

To solution of sodium methoxide (7.52 g) in methanol (130 ml) was added cyanoacetamide (5.84 g) followed by 2-(4-chlorophenyl)-3-dimethylaminopropenal and the resulting suspension was refluxed overnight. During this time a yellow solid was formed. The mixture was cooled to room temperature and glacial acetic add (50 ml) was added followed by water (100 ml). The resulting yellow orange solid was filtered off, washed several times with water and dried to yield 8.1 g of 3-cyano-5-(4-chlorophenyl)-2-pyridinone.

出典