反応 #1596952

反応方程式

1,2-dibromoethane

n-butyl lithium hexane

THF

dibenzofuran

→

Compound 16-1

Bromodibenzofuran

溶媒

Water

反応条件

後処理

1. 1
   温度The obtained solution is again cooled to −78° C.
2. 2
   温度the temperature of the solution is raised to room temperature over 120 minutes
3. 3
   その他the reaction
4. 4
   抽出Organic layers extracted from the obtained mixture with ethyl acetate
5. 5
   乾燥are dried with sodium sulfate
6. 6
   濃縮concentrated with an evaporator

実験手順

Under nitrogen current at −78° C., an n-butyl lithium hexane solution (1.6M, 69 ml) is dropped to a THF solution (175 ml) containing 16.82 g of dibenzofuran, and the temperature of the mixture is raised to room temperature over 80 minutes. The obtained solution is again cooled to −78° C., 19.0 ml of 1,2-dibromoethane is added to the solution, and the temperature of the solution is raised to room temperature over 120 minutes. Water is added to the obtained reaction solution to stop the reaction. Organic layers extracted from the obtained mixture with ethyl acetate are dried with sodium sulfate, and then concentrated with an evaporator to obtain 12.35 g of Compound 16-1.

出典