反応 #1596945

反応方程式

2-(4-benzyloxy-3-fluorophenyl)-4-bromo-5-propyltetrahydropyran

triethylamine

→

2-fluoro-4-(5-propyltetrahydropyran-2-yl)phenol

溶媒

MTBE

toluene water

反応条件

後処理

1. 1
   その他the organic phase is separated off
2. 2
   抽出The aqueous phase is extracted with MTBE
3. 3
   洗浄The combined organic phases are washed with water
4. 4
   その他dried
5. 5
   濃縮The solution is concentrated to dryness
6. 6
   その他the residue is used directly for the following reaction

実験手順

123.0 g (0.30 mol) of 2-(4-benzyloxy-3-fluorophenyl)-4-bromo-5-propyltetrahydropyran are hydrogenated in toluene/water in the presence of Pd/C (5% of Pd) and 86.0 ml (0.60 mol) of triethylamine. The reaction solution is diluted with MTBE, and the organic phase is separated off. The aqueous phase is extracted with MTBE. The combined organic phases are washed with water and dried using sodium sulfate. The solution is concentrated to dryness, and the residue is used directly for the following reaction.

出典