反応 #1596942

反応方程式

4-bromo-2-fluorophenol

potassium carbonate

benzyl bromide

→

1-benzyloxy-4-bromo-2-fluorobenzene

溶媒

ethyl methyl ketone

反応条件

後処理

1. 1
   温度The mixture is refluxed for 5 h
2. 2
   ろ過The batch is filtered
3. 3
   濃縮the filtrate is concentrated to dryness
4. 4
   その他The crude product is crystallised from heptane at reduced temperature

実験手順

210.0 g (1.10 mol) of 4-bromo-2-fluorophenol are dissolved in 1.1 l of ethyl methyl ketone, and 175.0 g (1.27 mol) of potassium carbonate and 150.0 ml (1.26 mol) of benzyl bromide are added. The mixture is refluxed for 5 h and stirred at room temperature for 16 h. The batch is filtered, and the filtrate is concentrated to dryness. The crude product is crystallised from heptane at reduced temperature.

出典