反応 #159615

反応方程式

azetidin-3-ol hydrochloride

methyl 2-chloro-5-(trifluoromethyl)nicotinate

→

title compound ( D67 )

収率 82.6%

methyl 2-(3-hydroxyazetidin-1-yl)-5-(trifluoromethyl)nicotinate

収率 82.6%

反応条件

実験手順

The title compound (D67) (4.0 g) was prepared according to the experimental procedure described in Description 62 starting from azetidin-3-ol hydrochloride (2.3 g, 21.03 mmol) and methyl 2-chloro-5-(trifluoromethyl)nicotinate (D66) (4.2 g, 17.53 mmol)

出典