反応 #1595873

反応方程式

(trimethylsilyl)diazo-methane

4-(4-aminophenyl)butanoic acid

MeOH

dichloromethane

→

methyl 4-(4-aminophenyl)butanoate

収率 28.0%

溶媒

THF

反応条件

後処理

1. 1
   workup.ADDITIONAfter the addition
2. 2
   その他The volatile material was removed under reduced pressure
3. 3
   その他the residue was purified by chromatography on silica gel

実験手順

To a solution of 4-(4-aminophenyl)butanoic acid (180 mg, 1 mmol) in a mixture of THF (4 ml), MeOH (1 ml) and dichloromethane (1 ml) in a 20-mL vial was added dropwise (trimethylsilyl)diazo-methane (1 ml, 2N in hexane) at 0° C. After the addition was complete, the resulting mixture was stirred at room temperature for 1 hr. The volatile material was removed under reduced pressure and the residue was purified by chromatography on silica gel using hexane/dichloromethane (2:1) followed by dichloromethane as eluent to give methyl 4-(4-aminophenyl)butanoate as an yellowish oil (55 mg, 28% yield).

出典