反応 #159381

反応方程式

3-tert-butoxycarbonylamino-5-(5-fluoropyridin-2-yl)-thiophene-2-carboxylic acid methyl ester

trifluoroacetic acid

→

3-Amino-5-(5-fluoropyridin-2-yl)thiophene-2-carboxylic acid methyl ester

溶媒

dichloromethane

反応条件

後処理

1. 1
   その他The solvent was then removed in vacuo
2. 2
   洗浄washed twice with saturated NaHCO3 solution and once with water
3. 3
   乾燥The dichloromethane phase was dried over sodium sulfate
4. 4
   濃縮concentrated
5. 5
   その他The product with the molecular weight of 252.27 (C11H9FN2O2S) was obtained in this way

実験手順

A solution of 3-tert-butoxycarbonylamino-5-(5-fluoropyridin-2-yl)-thiophene-2-carboxylic acid methyl ester (80 mg) in dichloromethane (1.35 mL) was mixed with trifluoroacetic acid (0.15 mL) and stirred at room temperature overnight. The solvent was then removed in vacuo, and the residue was taken up again in dichloromethane and washed twice with saturated NaHCO3 solution and once with water. The dichloromethane phase was dried over sodium sulfate and concentrated. The product with the molecular weight of 252.27 (C11H9FN2O2S) was obtained in this way; MS (ESI): 253 (M+H+).

出典