反応 #159376

反応方程式

4-fluoro-2-methyl-1-nitrobenzene

dimethylpyrrolidin-3-ylamine

potassium carbonate

→

Dimethyl-[1-(3-methyl-4-nitrophenyl)pyrrolidin-3-yl]amine

溶媒

DMF

反応条件

後処理

1. 1
   その他The reaction mixture was partitioned between water and ethyl acetate
2. 2
   その他The organic phase was dried
3. 3
   濃縮concentrated
4. 4
   その他The product with the molecular weight of 249.32 (C13H19N3O2) was obtained in this way

実験手順

A mixture of 4-fluoro-2-methyl-1-nitrobenzene (13.6 g), dimethylpyrrolidin-3-ylamine (10.0 g), potassium carbonate (12 g) and DMF (100 mL) was stirred at room temperature for 4 hours. The reaction mixture was partitioned between water and ethyl acetate. The organic phase was dried and concentrated. The product with the molecular weight of 249.32 (C13H19N3O2) was obtained in this way; MS (ESI): 250 (M+H+).

出典