反応 #1592132

反応方程式

compound 27

methyl 4-(4-aminophenyl)butanoate

NH4OH

→

compound 33

収率 70.0%

4-(4-aminophenyl)butanamide

収率 70.0%

溶媒

CH3OH

反応条件

後処理

1. 1
   workup.STIRRINGThe reaction mixture was stirred at room temperature for 6 h
2. 2
   濃縮concentrated in vacuo
3. 3
   workup.ADDITIONThe residue was diluted with water
4. 4
   抽出extracted with DCM/CH3OH (10:1)
5. 5
   乾燥The combined organic layers were dried over Na2SO4
6. 6
   濃縮concentrated to dryness

実験手順

To a solution of compound 27 (300 mg, 1.55 mmol) in CH3OH (5 mL) was added NH4OH (32) at room temperature with stirring. The reaction mixture was stirred at room temperature for 6 h and concentrated in vacuo. The residue was diluted with water and extracted with DCM/CH3OH (10:1). The combined organic layers were dried over Na2SO4 and concentrated to dryness to give compound 33 (194 mg, 70%) as a white solid. The crude product was used directly for the next step without purification.

出典