反応 #1592130

反応方程式

compound 27

methyl 4-(4-aminophenyl)butanoate

CH3NH2 CH3OH

→

compound 30

収率 95.0%

4-(4-aminophenyl)-N-methylbutanamide

収率 95.0%

反応条件

後処理

1. 1
   濃縮The reaction mixture was concentrated to dryness

実験手順

A solution of compound 27 (450 mg, 2.33 mmol) in CH3NH2/CH3OH (29, 50 mL) was stirred at room temperature for overnight. The reaction mixture was concentrated to dryness to give compound 30 (450 mg, 95%) as a white solid. The crude product was used directly for the next step without purification. 1H NMR (400 MHz, CDCl3) δ6.95 (d, 2H, J=8.3 Hz), 6.61 (d, 2H, J=8.3 Hz), 5.30 (br s, 1H), 3.50 (br s, 2H), 2.78 (d, 3H, J=4.8 Hz), 2.54 (t, 2H, J=7.4 Hz), 2.14 (t, 2H, J=7.4 Hz), 1.85-1.95 (m, 2H).

出典