反応 #159107

ord-27791ed57d544c919df6bed3c5b28466

反応方程式

CC(C)(C)OC(=O)N1C2CCC(C2)C1C(=O)NCC(=O)c1ccc(Br)cc1
3-[2-(4-Bromo-phenyl)-2-oxo-ethylcarbamoyl]-2-aza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester
CC(C)(C)OC(=O)N1C2CCC(C2)C1C(=O)O
2-aza-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid 2-tert-butyl ester
→
CC(C)(C)OC(=O)N1CCOCC1C(=O)NCC(=O)c1ccc(Br)cc1
Title compound
CC(C)(C)OC(=O)N1CCOCC1C(=O)NCC(=O)c1ccc(Br)cc1
3-[2-(4-Bromo-phenyl)-2-oxo-ethylcarbamoyl]-morpholine-4-carboxylic acid tert-butyl ester

反応物

CC(C)(C)OC(=O)N1C2CCC(C2)C1C(=O)NCC(=O)c1ccc(Br)cc1
3-[2-(4-Bromo-phenyl)-2-oxo-ethylcarbamoyl]-2-aza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester
CC(C)(C)OC(=O)N1C2CCC(C2)C1C(=O)O
2-aza-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid 2-tert-butyl ester

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

Title compound was prepared according to the method employed to prepare 3-[2-(4-Bromo-phenyl)-2-oxo-ethylcarbamoyl]-2-aza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester (Example AE), substituting Morpholine-3,4-dicarboxylic acid 4-tert-butyl ester for 2-aza-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid 2-tert-butyl ester.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US08822430B2uspto-grants-2014_09