反応 #159006

反応方程式

2-[5-(4-Bromo-naphthalen-1-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carboxylic acid tert-butyl ester

trifluoroacetic acid

→

5-(4-bromo-naphthalen-1-yl)-2-pyrrolidin-2-yl-1H-imidazole

収率 121.5%

溶媒

DCM

反応条件

後処理

1. 1
   その他evaporated under vacuum
2. 2
   workup.DISSOLUTIONSolid was dissolved in DCM (10 mL)
3. 3
   抽出extracted with saturated NaHCO3 solution (30 mL)
4. 4
   ろ過A solid was collected by vacuum filtration
5. 5
   洗浄washed with DCM
6. 6
   その他dried under vacuum

実験手順

2-[5-(4-Bromo-naphthalen-1-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carboxylic acid tert-butyl ester (1.00 g) was dissolved in DCM (12 mL), and trifluoroacetic acid (4 mL) was added. The reaction mixture was stirred at ambient temperature for 3 hours and evaporated under vacuum. Solid was dissolved in DCM (10 mL) and extracted with saturated NaHCO3 solution (30 mL). A solid was collected by vacuum filtration, washed with DCM, and dried under vacuum, giving 5-(4-bromo-naphthalen-1-yl)-2-pyrrolidin-2-yl-1H-imidazole (0.940 g, crude) as an off-white solid.

出典