反応 #1587

反応方程式

3-(4-chlorobenzoyl)propionic acid

hydrazine monohydrate

→

6-(4-chlorophenyl)-4,5-dihydropyridazinone

収率 80.0%

溶媒

ethanol

反応条件

後処理

1. 1
   その他A thick solid was formed which
2. 2
   workup.DISSOLUTIONdissolved
3. 3
   温度after heating
4. 4
   温度The resulting solution was refluxed for 3 h
5. 5
   温度cooled
6. 6
   その他the solid formed
7. 7
   ろ過filtered
8. 8
   その他dried

実験手順

To a solution of 3-(4-chlorobenzoyl)propionic acid (20g) in absolute ethanol (200 ml) was added 5 g of hydrazine monohydrate. A thick solid was formed which dissolved after heating. The resulting solution was refluxed for 3 h, cooled and the solid formed filtered and dried to yield 16 g (80%) of 6-(4-chlorophenyl)-4,5-dihydropyridazinone.

出典