反応 #1586

反応方程式

Raloxifene HCl

triethylamine

linolenoyl chloride

→

Raloxifene

溶媒

THF

反応条件

後処理

1. 1
   その他This derivative was prepared in a manner similar to Example 1
2. 2
   その他The final product was chromatographed on a silica gel column
3. 3
   洗浄eluted with EtOAc-hexane (8:2)

実験手順

This derivative was prepared in a manner similar to Example 1, using 2.6 g (0.005 mol) of Raloxifene HCl, 2 g (0.02 mol) of triethylamine, 20 mg of DMAP, and 3.2 g (0.01 mol) of linolenoyl chloride in 250 mL of THF. The final product was chromatographed on a silica gel column eluted with EtOAc-hexane (8:2). This yielded 3.21 g of the title compound as clear oil.

出典