反応 #158580

反応方程式

N2,N4-bis(3-hydroxyphenyl)-5-fluoro-2,4-pyrimidinediamine

5-bromo-2,4-dichloropyrimidine

3-aminophenol

→

N2,N4-bis(3-hydroxyphenyl)-5-bromo-2,4-pyrimidinediamine

反応条件

後処理

1. 1
   その他were reacted

実験手順

In a manner similar to the preparation of N2,N4-bis(3-hydroxyphenyl)-5-fluoro-2,4-pyrimidinediamine, 5-bromo-2,4-dichloropyrimidine and 3-aminophenol were reacted to yield N2,N4-bis(3-hydroxyphenyl)-5-bromo-2,4-pyrimidinediamine. 1H NMR (DMSO-d6): δ 9.99 (bs, 1H), 9.34 (bs, 1H), 8.30 (s, 1H), 7.15 (t, 1H, J=8.4 Hz), 7.06-6.97 (m, 2H), 6.94-6.92 (m, 2H), 6.80 (bs, 1H), 6.62 (s, 1H, J=8.1 Hz), 6.43 (d, 1H, J=7.8 Hz); LCMS: ret. time: 18.48 min.; purity: 97%; MS (m/e): 374 (MH+).

出典