反応 #158418

反応方程式

HCl

NaOH

ethyl 3-(1-(3,4-difluorophenyl)cyclohexyl)propanoate

NaOH

→

3-(1-(3,4-difluorophenyl)cyclohexyl) propanoic acid

収率 100.0%

溶媒

MeOH

反応条件

後処理

1. 1
   workup.STIRRINGto stir for 3 hrs
2. 2
   抽出the product was extracted with EtOAc
3. 3
   洗浄The extract was washed with water and brine
4. 4
   乾燥dried over Na2SO4
5. 5
   その他evaporated

実験手順

To a solution of ethyl 3-(1-(3,4-difluorophenyl)cyclohexyl)propanoate (540 mg, 1.822 mmol) in MeOH (15 mL) was added 1N NaOH (3.64 mL, 3.64 mmol), and the mixture was stirred at room temperature for 20 hrs. Since the reaction was not complete on TLC, an additional 1.82 mL of 1N NaOH was added, and it was continued to stir for 3 hrs. TLC showed that the reaction was complete. Next, the reaction mixture was acidified with the addition of 6 mL of 1N HCl, and the product was extracted with EtOAc. The extract was washed with water and brine, dried over Na2SO4, and evaporated to give 3-(1-(3,4-difluorophenyl)cyclohexyl) propanoic acid (489 mg, 1.822 mmol, 100% yield) as a white solid.

出典