反応 #158417

反応方程式

(E)-ethyl 3-(1-(3,4-difluorophenyl)cyclohexyl)acrylate

→

ethyl 3-(1-(3,4-difluorophenyl)cyclohexyl)propanoate

溶媒

MeOH

反応条件

後処理

1. 1
   その他The catalyst was removed
2. 2
   ろ過by filtering through Celite
3. 3
   その他the solvent was evaporated off

実験手順

To a solution of (E)-ethyl 3-(1-(3,4-difluorophenyl)cyclohexyl)acrylate (550 mg, 1.869 mmol) in MeOH (20 mL) was added ˜150 mg of 10% Pd/C (wet, 50%), and the mixture was stirred under hydrogen (50 psi) for 6 hrs. The catalyst was removed by filtering through Celite and the solvent was evaporated off to give ethyl 3-(1-(3,4-difluorophenyl)cyclohexyl)propanoate as an oil. LC/MS: m/e 297.16 (M+H)+.

出典