反応 #1583897

反応方程式

D-Leucine

HBr

sodium nitrite

→

Intermediate ( 9a )

収率 86.0%

(R)-2-Bromo-4-methylpentanoic acid

収率 86.0%

溶媒

water

water

反応条件

後処理

1. 1
   抽出extracted twice with EtOAc
2. 2
   洗浄washed twice with saturated aqueous NaCl
3. 3
   乾燥dried over MgSO4
4. 4
   ろ過filtered
5. 5
   濃縮concentrated

実験手順

D-Leucine (9.9 g, 75.2 mmol) was dissolved in 3M HBr in water (120 mL) and cooled to 0° C. A solution of sodium nitrite (8.3 g, 120 mmol) in water (20 mL, 100 mmol) was added. The mixture was stirred at 0° C. for 2.5 hours, extracted twice with EtOAc, washed twice with saturated aqueous NaCl, dried over MgSO4, filtered, and concentrated to afford 12.6 g (86%) of Intermediate (9a) as a pale yellow oil. This was taken on to the next step without further purification.

出典