反応 #1583893

反応方程式

2-Fluoro-4-methylbenzoic acid

MeOH

HCl

→

Intermediate ( 6a )

2-Fluoro-4-methylbenzoic acid methyl ester

反応条件

後処理

1. 1
   温度The mixture was heated
2. 2
   温度to reflux
3. 3
   温度cooled
4. 4
   濃縮concentrated
5. 5
   その他The recovered material was dried in vacuo for 24 hours

実験手順

2-Fluoro-4-methylbenzoic acid (30.0 g, 195 mmol) was dissolved in MeOH (600 mL, 10 mol), and 12 M HCl (3.2 mL, 39 mmol) was added. The mixture was heated to reflux and stirred for 48 hours, then cooled and concentrated. The recovered material was dried in vacuo for 24 hours to obtain Intermediate (6a) as a white solid that was used without further purification.

出典