反応 #1583890

反応方程式

7-Methyl-2-propyl-3H-benzoimidazole-5-carboxylic acid

MeOH

hydrogen chloride

→

title compound

7-Methyl-2-propyl-3H-benzoimidazole-5-carboxylic Acid Methyl Ester

反応条件

後処理

1. 1
   workup.ADDITIONadded to a round bottom flask
2. 2
   温度The mixture was refluxed for 12 hours
3. 3
   濃縮then concentrated under reduced pressure

実験手順

7-Methyl-2-propyl-3H-benzoimidazole-5-carboxylic acid (30.0 g, 137 mmol) was dissolved in MeOH (550 mL) and added to a round bottom flask, followed by the addition of 20 mL of a hydrogen chloride solution (30:70, conc. HCl:water). The mixture was refluxed for 12 hours then concentrated under reduced pressure to afford the title compound as a yellow solid (31.8 g, 137 mmol). MS m/z: [M+H+] calcd for C13H16N2O2, 233.12. found 233.2.

出典