反応 #1583879

反応方程式

2,2-diphenyl ethanol

triethylamine

MsCl

→

2,2-diphenylethyl methanesulfonate

収率 96.8%

溶媒

dichloromethane

—

three-opening

反応条件

後処理

1. 1
   その他was conducted at 25° C
2. 2
   その他After the completion of reaction
3. 3
   洗浄the reaction solution was washed with water thrice
4. 4
   乾燥The organic phase was dried over anhydrous sodium sulfate
5. 5
   その他evaporated
6. 6
   その他to remove the solvent

実験手順

In a 500 mL three-opening flask, 2,2-diphenyl ethanol (17 g, 86 mmol) was dissolved in 170 mL dichloromethane. To the flask was added triethylamine (13.03 g, 129 mmol). The resulting mixture was stirred at 0° C. for half an hour. To the resulting mixture was slowly added MsCl (11.92 g, 104 mmol) dropwisely. The reaction was conducted at 25° C. After the completion of reaction monitored by TLC, the reaction solution was washed with water thrice. The organic phase was dried over anhydrous sodium sulfate and evaporated to remove the solvent to produce 2,2-diphenylethyl methanesulfonate (23 g) in a yield of 96.78%.

出典