反応 #1583868

反応方程式

Thionyl chloride

5-methoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid

→

crude product

methyl 5-chlorocarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate

溶媒

dichloromethane

反応条件

後処理

1. 1
   workup.ADDITIONAfter the completion of the dropwise addition
2. 2
   温度under cooling in an ice bath until the solution
3. 3
   その他After the completion of reaction
4. 4
   その他the reaction solution was rotary evaporated to dryness

実験手順

Thionyl chloride (0.4 g, 3.4 mmol) was slowly added to a solution of 5-methoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid (1.0 g, 3 mmol) in dichloromethane dropwisely at −25° C. After the completion of the dropwise addition, the reaction was continued under cooling in an ice bath until the solution became clear. After the completion of reaction, the reaction solution was rotary evaporated to dryness to produce a crude product, which was directly used in the next step.

出典