反応 #1583859

反応方程式

oxybutynin hydrochloride

→

Oxybutynin

溶媒

water

反応条件

後処理

1. 1
   workup.ADDITIONslowly adding 1586 g of AMBERLITE™
2. 2
   workup.ADDITIONThe dispersion was mixed for 4 hours
3. 3
   その他before decanting the supernatant
4. 4
   その他The wet resin complex was then dried in a VWR™ convention oven
5. 5
   workup.ADDITIONKOLLICOAT™ SR-30D polymer system (540 g) was then slowly added to the wet resin complex in a Hobart type mixer (Kitchen Aid)
6. 6
   その他to form a uniform mass
7. 7
   その他The wet mass was again dried in a 50° C
8. 8
   その他The semi-dried granules were then milled through a 40 mesh screen
9. 9
   その他continued drying at 50° C. until the moisture content
10. 10
    その他The dried granules were then milled through a 40 mesh screen

実験手順

The Oxybutynin Resin Complex was prepared by first dissolving 300 g of oxybutynin hydrochloride in 8 L of purified water, and then slowly adding 1586 g of AMBERLITE™ IRP-69 resin with continuous mixing. The pH was adjusted to 3.9. The dispersion was mixed for 4 hours, and upon completion, allowed to settle before decanting the supernatant. The slurring/decanting process was repeated twice with sufficient amounts of purified water. The wet resin complex was then dried in a VWR™ convention oven maintained at 50° C. until moisture content was about 25%. KOLLICOAT™ SR-30D polymer system (540 g) was then slowly added to the wet resin complex in a Hobart type mixer (Kitchen Aid) to form a uniform mass. The wet mass was again dried in a 50° C. VWR™ convention oven to the moisture content about 25%. The semi-dried granules were then milled through a 40 mesh screen using CO-MIL™ and continued drying at 50° C. until the moisture content was between 3-7%. The dried granules were then milled through a 40 mesh screen using CO-MIL™.

出典