反応 #1583845

ord-c0cee37d136744ac9d98e9f815a00009

反応方程式

NC(=O)CC[C@H](N)C(=O)O
L-(+)-glutamine
O=C=Nc1cccc(Cc2ccccc2)c1
3-benzylphenyl isocyanate
→
NC(=O)CC[C@H](NC(=O)Nc1cccc(Cc2ccccc2)c1)C(=O)O
N2-[(3-benzylphenylamino)carbonyl]-L-glutamine
収率 73.0%

反応物

NC(=O)CC[C@H](N)C(=O)O
L-(+)-glutamine
O=C=Nc1cccc(Cc2ccccc2)c1
3-benzylphenyl isocyanate

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

Preparation from L-(+)-glutamine (0.487 g, 3.33 mmol) and 3-benzylphenyl isocyanate (0.719 g, 3.33 mmol) (final pH value after 24 h stirring: 5-6) gave N2-[(3-benzylphenylamino)carbonyl]-L-glutamine (0.862 g, 73%, white solid).

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US09198845B2uspto-grants-2015_12