反応 #1583822

反応方程式

[3-(4-chlorophenyl)-1-ethyl-1H-1,2,4-triazol-5-yl]acetic acid

DMF

oxalyl chloride

→

[3-(4-chlorophenyl)-1-ethyl-1H-1,2,4-triazol-5-yl]acetyl chloride

溶媒

dichloromethane

dichloromethane

反応条件

後処理

1. 1
   workup.ADDITIONare added dropwise
2. 2
   濃縮concentrated under reduced pressure

実験手順

1.2 mmol (318 mg) of [3-(4-chlorophenyl)-1-ethyl-1H-1,2,4-triazol-5-yl]acetic acid and 0.1 mmol (7 mg) of DMF are dissolved in 5 ml of anhydrous dichloromethane 1.3 mmol of oxalyl chloride (163 mg) in 3 ml of anhydrous dichloromethane are added dropwise. The solution is stirred at room temperature for 8 h and then concentrated under reduced pressure. The [3-(4-chlorophenyl)-1-ethyl-1H-1,2,4-triazol-5-yl]acetyl chloride obtained in this manner is processed further in crude form.

出典