反応 #1583811

反応方程式

N-bromosuccinimide

2-ethyl-4-(4-fluorophenyl)-1,3-thiazole

water

→

5-Bromo-2-ethyl-4-(4-fluorophenyl)-1,3-thiazole

溶媒

dichloromethane

反応条件

後処理

1. 1
   その他the organic phase is separated off
2. 2
   洗浄washed with saturated NHCO3 solution
3. 3
   乾燥dried over MgSO4
4. 4
   濃縮concentrated under reduced pressure

実験手順

At room temperature, 1.72 g (9.64 mmol) of N-bromosuccinimide are added a little at a time to a solution of 2.00 g (9.64 mmol) of 2-ethyl-4-(4-fluorophenyl)-1,3-thiazole in 40 ml of dichloromethane. After 2 h, 50 ml of water are added to the reaction mixture, and the organic phase is separated off, washed with saturated NHCO3 solution, dried over MgSO4 and concentrated under reduced pressure. This gives 2.47 g (85%) of the desired product; 1H-NMR(DMSO-d6) δ: 7.92 (m, 2H), 7.32 (m, 2H), 3.02 (q, 2H), 1.31 (t, 3H).

出典