反応 #1583809

反応方程式

propanethioamide

2-bromo-1-(4-fluorophenyl)-2-(4-pyridyl)ethanone hydrobromide

→

4-[2-Ethyl-4-(4-fluorophenyl)-1,3-thiazol-5-yl]pyridine

溶媒

DMF

反応条件

後処理

1. 1
   その他At room temperature
2. 2
   workup.ADDITIONare added
3. 3
   抽出the mixture is extracted with ethyl acetate (3×100 ml)
4. 4
   洗浄The combined organic phases are washed with water (2×100 ml)
5. 5
   乾燥dried over MgSO4
6. 6
   その他The crude product is then purified by column chromatography on silica gel (cyclohexane/ethyl acetate)

実験手順

At room temperature, 1.31 g (14.7 mmol) propanethioamide are added to a solution of 5.00 g (13.3 mmol) of 2-bromo-1-(4-fluorophenyl)-2-(4-pyridyl)ethanone hydrobromide (described, for example, in Chem. Pharm. Bull. 2005, 53, 410-418) in 30 ml of DMF, and the mixture is stirred for 16 h. Subsequently, the reaction mixture is stirred into 100 ml of ice-water, 50 ml of a saturated aqueous Na—HCO3 are added and the mixture is extracted with ethyl acetate (3×100 ml). The combined organic phases are washed with water (2×100 ml), dried over MgSO4 and freed from the solvent under reduced pressure. The crude product is then purified by column chromatography on silica gel (cyclohexane/ethyl acetate). This gives 2.85 g (75%) of the desired product; 1H-NMR (DMSO-d6) δ: 8.53 (d, 2H), 7.47 (m, 2H), 7.26 (d, 2H), 7.17 (m, 2H), 3.05 (q, 2H), 1.37 (t, 3H).

出典