反応 #158320

反応方程式

methyl 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzoate

hydrochloric acid

Water

→

title compound

収率 53.5%

3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzoic acid

収率 53.5%

溶媒

sodium hydroxide

methanol

反応条件

後処理

1. 1
   ろ過the precipitate was collected by filtration
2. 2
   洗浄The solid was washed with ethyl acetate and water

実験手順

A mixture of methyl 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzoate (16.0 g) in 2N aqueous sodium hydroxide solution (65 mL) and methanol (100 mL) was stirred at room temperature for 1 hr, and the mixture was acidified with 6N hydrochloric acid (pH=3-4). Water was added to the reaction mixture, and the precipitate was collected by filtration. The solid was washed with ethyl acetate and water to give the title compound (8.07 g). To the filtrate was added saturated brine, and the mixture was extracted with ethyl acetate/2-propanol. The organic layers were combined, washed with saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was washed with ethyl acetate to give the title compound (4.10 g).

出典