反応 #158293

反応方程式

Lawesson's reagent

ethyl 3-(3,4-difluorophenyl)-2-oxopiperidine-3-carboxylate

→

title compound

収率 116.1%

ethyl 3-(3,4-difluorophenyl)-2-thioxopiperidine-3-carboxylate

収率 116.1%

溶媒

toluene

反応条件

後処理

1. 1
   温度to cool to room temperature
2. 2
   その他the solvent was evaporated under reduced pressure
3. 3
   その他The residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane)

実験手順

Under an argon atmosphere, Lawesson's reagent (1.00 g) was added to a suspension of ethyl 3-(3,4-difluorophenyl)-2-oxopiperidine-3-carboxylate (1.00 g) in toluene (20 mL) at room temperature. The reaction mixture was stirred at 110° C. for 4 hr, and allowed to cool to room temperature, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane) to give the title compound (859 mg).

出典