反応 #158129

反応方程式

7-chloro-5-methoxy-1H-benzotriazole

4-methoxy-2-nitroaniline

N-chlorosuccinimide

3-chloro-1,2-diamino-5-methoxybenzene

→

2-amino-3-(4-chloro-6-methoxy-2H-benzotriazol-2-yl)-2-methylpropionitrile

7-Chloro-5-methoxy-1H-benzotriazole

3-Chloro-1,2-diamino-5-methoxybenzene

収率 75.0%

6-chloro-4-methoxy-2-nitroaniline

収率 14.0%

反応条件

実験手順

2-amino-3-(4-chloro-6-methoxy-2H-benzotriazol-2-yl)-2-methylpropionitrile was prepared using a procedure similar to that described in Example 1, part a and b, except starting from 7-chloro-5-methoxy-1H-benzotriazole. 7-Chloro-5-methoxy-1H-benzotriazole (0.8 g) was prepared using a procedure similar to that described in Example 13, part a, except starting from 3-chloro-1,2-diamino-5-methoxybenzene. 3-Chloro-1,2-diamino-5-methoxybenzene (1.88 g, 75%) was prepared using a procedure similar to that described in Example 38, part a and b, except starting from 4-methoxy-2-nitroaniline (16.8 g) and N-chlorosuccinimide (15 g) in part a to yield 6-chloro-4-methoxy-2-nitroaniline (2.9 g, 14%) used in part b.

出典