反応 #1578277

ord-d73c3a5f7af3448f99fa4b705ae2ed25

反応方程式

O=C1c2ccccc2C(=O)N1C1(C(=O)Nc2c(F)c(F)c(C(F)(F)F)c(F)c2F)CCC1
O=C1c2ccccc2C(=O)N1C
→
CC1(C)OB(C2CCC2(C(=O)Nc2c(F)c(F)c(C(F)(F)F)c(F)c2F)N2C(=O)c3ccccc3C2=O)OC1(C)C
CC1(C)OB(C2CCC2(C(=O
収率 72.0%

反応物

O=C1c2ccccc2C(=O)N1C1(C(=O)Nc2c(F)c(F)c(C(F)(F)F)c(F)c2F)CCC1
O=C1c2ccccc2C(=O)N1C1(C(=O)Nc2
CAS: 1582806-63-0

試薬

CC(=O)O.[Pd]
CC(=O)O.[Pd]
CAS: 3375-31-3
COc1cc(OC)c2ccccc2n1
COc1cc(OC)c2ccccc2n1
CAS: 40335-00-0
CC(=O)O
CC(=O)O
CAS: 64-19-7
O=C(O)O.[K]
O=C(O)O.[K]
CAS: 298-14-6
CC[N+](CC)(CC)CC.F[B-](F)(F)F
CC[N+](CC)(CC)CC.F[B-](F)(F)F
CAS: 429-06-1
CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C
CC1(C)OB(B2OC(C)(C)C(C)(C)O2)O
CAS: 73183-34-3

溶媒

CC#N
CC#N
CAS: 75-05-8

反応条件

温度
80°CELSIUS

出典

DOI: 10.1002/anie.201509996Borylation dataset from Roche