反応 #1578275

ord-23450aa4292b4ff2ae65b869487b8d7c

反応方程式

CC(C(=O)Nc1c(F)c(F)c(C(F)(F)F)c(F)c1F)N1C(=O)c2ccccc2C1=O
CC(C(=O)Nc1c(F)c(F)c
→
CC1(C)OB(CC(C(=O)Nc2c(F)c(F)c(C(F)(F)F)c(F)c2F)N2C(=O)c3ccccc3C2=O)OC1(C)C
CC1(C)OB(CC(C(=O)Nc2
収率 73.0%

反応物

CC(C(=O)Nc1c(F)c(F)c(C(F)(F)F)c(F)c1F)N1C(=O)c2ccccc2C1=O
CC(C(=O)Nc1c(F)c(F)c(C(F)(F)F)
CAS: 1582806-46-9

試薬

CC(=O)O.[Pd]
CC(=O)O.[Pd]
CAS: 3375-31-3
COc1cc(OC)c2ccccc2n1
COc1cc(OC)c2ccccc2n1
CAS: 40335-00-0
CC(=O)O
CC(=O)O
CAS: 64-19-7
CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C
CC1(C)OB(B2OC(C)(C)C(C)(C)O2)O
CAS: 73183-34-3
CC[N+](CC)(CC)CC.F[B-](F)(F)F
CC[N+](CC)(CC)CC.F[B-](F)(F)F
CAS: 429-06-1
O=C(O)O.[K]
O=C(O)O.[K]
CAS: 298-14-6

溶媒

CC#N
CC#N
CAS: 75-05-8

反応条件

温度
80°CELSIUS

出典

DOI: 10.1002/anie.201509996Borylation dataset from Roche