反応 #1578271

ord-95b2f67a4ec6405689bf70d5935fe704

反応方程式

COC(=O)C12CCC(C(=O)Nc3c(F)c(F)c(C(F)(F)F)c(F)c3F)(CC1)CC2
COC(=O)C12CCC(C(=O)N
→
COC(=O)C12CCC(C(=O)Nc3c(F)c(F)c(C(F)(F)F)c(F)c3F)(CC1)C(B1OC(C)(C)C(C)(C)O1)C2
COC(=O)C12CCC(C(=O)N
収率 80.0%

反応物

COC(=O)C12CCC(C(=O)Nc3c(F)c(F)c(C(F)(F)F)c(F)c3F)(CC1)CC2
COC(=O)C12CCC(C(=O)Nc3c(F)c(F)
CAS: 1835284-19-9

試薬

CC(=O)O.[Pd]
CC(=O)O.[Pd]
CAS: 3375-31-3
CC[N+](CC)(CC)CC.F[B-](F)(F)F
CC[N+](CC)(CC)CC.F[B-](F)(F)F
CAS: 429-06-1
CC(=O)O
CC(=O)O
CAS: 64-19-7
O=C(O)O.[K]
O=C(O)O.[K]
CAS: 298-14-6
CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C
CC1(C)OB(B2OC(C)(C)C(C)(C)O2)O
CAS: 73183-34-3
COc1cc(OC)c2ccccc2n1
COc1cc(OC)c2ccccc2n1
CAS: 40335-00-0

溶媒

CC#N
CC#N
CAS: 75-05-8

反応条件

温度
80°CELSIUS

出典

DOI: 10.1002/anie.201509996Borylation dataset from Roche