反応 #157823

反応方程式

Anisole

6-{(E)-1-(4-tert-butylphenyl)-2-[(2R)-1-(2,4-dimethoxybenzyl)-5-oxopyrrolidin-2-yl]ethenyl}-3-methoxypyridin-2(1H)-one

→

title compound

収率 62.9%

6-{(E)-1-(4-tert-Butylphenyl)-2-[(2R)-5-oxopyrrolidin-2-yl]ethenyl}-3-methoxypyridin-2(1H)-one

収率 62.9%

溶媒

trifluoroacetic acid

反応条件

後処理

1. 1
   その他The solvent was evaporated under reduced pressure
2. 2
   その他The residue was purified by silica gel column chromatography (chloroform:methanol=1:0→9:1)

実験手順

Anisole (1 mL) was added to a solution of 6-{(E)-1-(4-tert-butylphenyl)-2-[(2R)-1-(2,4-dimethoxybenzyl)-5-oxopyrrolidin-2-yl]ethenyl}-3-methoxypyridin-2(1H)-one (65 mg) in trifluoroacetic acid (2 mL), and the mixture was stirred at 80° C. for nine hours. The solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (chloroform:methanol=1:0→9:1) to give the title compound as a colorless powder (29 mg).

出典