反応 #1575

反応方程式

4'-chloro-2'-fluoro-5'-nitroacetanilide

hydrogen

→

title product

5'-Amino-4'-chloro-2'-fluoroacetanilide

溶媒

ethanol tetrahydrofuran

反応条件

後処理

1. 1
   ろ過The reaction mixture is then filtered
2. 2
   濃縮concentrated in vacuo

実験手順

A mixture of 4'-chloro-2'-fluoro-5'-nitroacetanilide (35.2 g, 151 mmol), and 5% platinum on carbon (7.0 g, 20 wt/wt %) in an ethanol/tetrahydrofuran (2:1) solution is hydrogenated until 28 psi of hydrogen is taken up. The reaction mixture is then filtered, and concentrated in vacuo to give the title product as a tan solid which is identified by 1H NMR spectral analysis.

出典