反応 #157287

反応方程式

methyl 4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-oxo-butyrate

methylhydrazine

→

product

収率 80.3%

2-(5-hydroxy-1-methyl-1H-pyrazol-3-ylmethyl)-isoindol-1,3-dione

収率 80.3%

溶媒

ethanol

反応条件

後処理

1. 1
   温度The reaction mixture is cooled
2. 2
   ろ過suction filtered
3. 3
   洗浄washed with ethanol

実験手順

10.0 g methyl 4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-oxo-butyrate are dissolved at 60° C. in 200 ml of ethanol and 1.94 g methylhydrazine are added. The reaction mixture is cooled and stirred further at ambient temperature. After 5 hours the precipitated substance is suction filtered and washed with ethanol. 7.91 g of the product are obtained as a powder.

出典