反応 #157148

反応方程式

HCl

picolinate

LiOH

→

picolinic acid

収率 98.0%

溶媒

THF

反応条件

後処理

1. 1
   その他the THF was removed in vacuo
2. 2
   ろ過The resulting solid was filtered
3. 3
   洗浄rinsed with cold H2O (3×20 mL)

実験手順

To a solution of methyl 3-amino-6-(2-fluoro-5-isopropylcabamoyl)phenyl)picolinate (1.0 equiv) in THF (0.5M), was added 1M LiOH (4.0 equiv). After stirring for 4 hours at 60° C., 1 N HCl (4.0 equiv.) was added and the THF was removed in vacuo. The resulting solid was filtered and rinsed with cold H2O (3×20 mL) to yield 3-amino-6-(2-fluoro-5-isopropylcabamoyl)phenyl)picolinic acid (98%). LCMS (m/z): 318.1 (MH+); LC Rt=2.4 min

出典