反応 #157029

反応方程式

4-chloro-3-nitroanisole

1-Boc-piperazine

→

tert-butyl 4-(4-methoxy-2-nitro phenyl)piperazine-1-carboxylate

収率 50.0%

溶媒

NMP

反応条件

後処理

1. 1
   その他at 100° C.
2. 2
   その他for 16 hours

実験手順

Method 1 was followed using 4-chloro-3-nitroanisole (1.0 eq), 1-Boc-piperazine (1.2 eq), and TEA (2.0 eq) in NMP at 100° C. for 16 hours yielding tert-butyl 4-(4-methoxy-2-nitro phenyl)piperazine-1-carboxylate (50%). LCMS (m/z): 338.2 (MH+); LC Rt=3.37 min.

出典