反応 #156682

反応方程式

acetic acid 1-oxo-5-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-indan-2-yl ester

potassium carbonate

water

→

2-Hydroxy-5-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-indan-1-one

溶媒

methanol

反応条件

後処理

1. 1
   抽出was extracted with dichloromethane
2. 2
   乾燥dried over magnesium sulfate
3. 3
   濃縮concentrated
4. 4
   その他In this way the product was obtained with molecular weight 248.28 (C14H16O4)

実験手順

A mixture of acetic acid 1-oxo-5-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-indan-2-yl ester (1.02 g) and potassium carbonate (264 mg) in methanol (1 mL) was stirred at room temperature for 1 h. After adding water it was extracted with dichloromethane, dried over magnesium sulfate and concentrated. In this way the product was obtained with molecular weight 248.28 (C14H16O4); MS (ESI): 249 (M+H+).

出典