反応 #156599

反応方程式

Trifluoromethanesulfonic acid 2-[4-((R)-3-dimethylaminopyrrolidin-1-yl)-3-fluorophenyl]-1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl ester

4-fluorophenylboronic acid

→

2-[4-((R)-3-Dimethylaminopyrrolidin-1-yl)-3-fluorophenyl]-6-(4-fluorophenyl)-3,4-dihydro-2H-isoquinolin-1-one

反応条件

後処理

1. 1
   その他The product with the molecular weight of 447.53 (C27H27F2N3O) was obtained in this way

実験手順

Trifluoromethanesulfonic acid 2-[4-((R)-3-dimethylaminopyrrolidin-1-yl)-3-fluorophenyl]-1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl ester was reacted with 4-fluorophenylboronic acid by method O. The product with the molecular weight of 447.53 (C27H27F2N3O) was obtained in this way; MS (ESI): 448 (M+H+).

出典