反応 #156598

ord-b5d62fd80fe848b1ba2addd59d948f38

反応方程式

CN(C)[C@@H]1CCN(c2ccc(N3CCc4cc(OS(=O)(=O)C(F)(F)F)ccc4C3=O)cc2F)C1
Trifluoromethanesulfonic acid 2-[4-((R)-3-dimethylaminopyrrolidin-1-yl)-3-fluorophenyl]-1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl ester
C1CCNCC1
piperidine
→
CN(C)[C@@H]1CCN(c2ccc(N3CCc4cc(N5CCCCC5)ccc4C3=O)cc2F)C1
2-[4-((R)-3-Dimethylaminopyrrolidin-1-yl)-3-fluorophenyl]-6-piperidin-1-yl-3,4-dihydro-2H-isoquinolin-1-one

反応物

CN(C)[C@@H]1CCN(c2ccc(N3CCc4cc(OS(=O)(=O)C(F)(F)F)ccc4C3=O)cc2F)C1
Trifluoromethanesulfonic acid 2-[4-((R)-3-dimethylaminopyrrolidin-1-yl)-3-fluorophenyl]-1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl ester
C1CCNCC1
piperidine

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    その他The product with the molecular weight of 436.58 (C26H33FN40) was obtained in this way

実験手順

Trifluoromethanesulfonic acid 2-[4-((R)-3-dimethylaminopyrrolidin-1-yl)-3-fluorophenyl]-1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl ester was reacted with piperidine by method N. The product with the molecular weight of 436.58 (C26H33FN40) was obtained in this way; MS (ESI): 437 (M+H+).

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US08822495B2uspto-grants-2014_09